According to new studies, breast cancer patients’ survival rates improve with stem cell therapy
A tumor-suppressing and killing molecule was engineered by Harvard Stem Cell Institute (HSCI) researchers.
In the study, it was demonstrated that the therapy successfully prolonged the lifespan of mice with breast cancer that metastasized to the brain.
When breast cancer patients develop brain metastases, there is nothing much that doctors can do. This is because brain metastatic cases are complex and sparse.
There is an urgency to find an alternative cure that is clinically translatable and they found it.
Brain metastasis (BM) affects 15 to 30% of metastatic breast cancer patients, with basal-like breast cancer (BLBC) being the most common.
The researchers began by analyzing tissue from breast tumors and metastatic tumors in the brains of BM patients.
They identified two cell death receptors and an overabundance of a growth factor receptor as critical targets that appeared to stimulate tumor growth.
Using this information, the researchers genetically developed a bi-functional chemical that targets both receptors at the same time and induces cell death in cancer cells.
Since breast cancer may spread to the brain in a variety of ways, the researchers spent three years developing mouse models that reflected the scope and complexity of the human disease.
One laboratory mouse represents metastasis in the form of a solid tumor in the middle of the brain (macro-metastasis), another represents a more distributed metastasis (perivascular niche micro-metastasis), and the third represents metastasis at the rear of the brain (leptomeningeal metastases). They are able to directly measure the efficacy of the new medicinal chemical using these models.
The researchers made use of a stem cell-based delivery mechanism to transport the chemical to the brain because stem cells have the benefit of being able to pass through the blood-brain barrier and home to tumors in the brain. The medication boosted survival rates in all three mouse models.
The purpose is to eventually mirror what happens in people. They transferred discoveries from patients to mice, and now they intend to return to the patients.
Stem cell delivery is immensely promising for treating breast cancer at stage 4.
Stem cell therapy has already been established as a safe treatment and tested in patients with trauma, stroke, epilepsy, and neurodegenerative diseases.
How Does Stem Cell Treatment Work?
There are two types of transplants. Your doctor will decide which is best for you.
In an autologous (AUTO) transplant, doctors take healthy stem cells from your bone marrow or blood. They’re frozen and carefully stored. Since they’re outside your body, they aren’t harmed during the chemotherapy or radiation treatments you’ll need to get rid of your cancer cells.
After your treatment ends, your thawed stem cells are returned to your bloodstream through an IV. They’ll find their way back to your bone marrow.
Once there, they can help your body make healthy blood cells again
Allogeneic transplantation involves receiving healthy stem cells from a donor.
It’s critical that the donor’s bone marrow matches yours exactly. Otherwise, your body may reject the cells. It’s possible that your donor is a family member. You can also obtain stem cells from someone you do not know.
You will receive chemotherapy, radiotherapy, or both prior to an allogeneic transplant. This destroys your own stem cells and prepares your body for new ones shortly after your treatment is completed.
If your doctor is unable to locate a donor, cells from donated umbilical cord blood may be used. Blood rich in stem cells stays in the removed cord and placenta after a baby is born. It is possible to freeze it and store it in a cord blood bank.
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The FGAAA has strict criteria for which stem cells are used in their treatments. They only use premium when it comes to stem cell therapies. A strict evaluation process happens to ensure the best interests of patients. The clinic offers potent stem cells that provide effective healing potential.
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Living Proof that Stem Cells Work!
Michael York and Lourdes Duque Baron, an author, producer, and actress, are ardent proponents of stem cell research.
New Breed of Homo Sapiens
Lourdes Duque Baron and Michael York can continue to live with tremendous vitality and immune systems thanks to the gradual advancements brought forth by stem cell therapy.
Recipients of billions of stem cells attest to the truth and efficacy of this revitalizing and enormously powerful treatment.
Michael York, a well-known actor, became an advocate for stem cells after being treated for amyloidosis and multiple myeloma. While Lourdes Duque Baron received stem cell therapy to treat her osteoporosis.
A New Breed of Homo Sapiens:
A new book about stem cells and their wonders was authored by Lou Baron and will soon be released.
New Breed of Homo Sapiens by Lourdes Duque Baron
“ Age should not define what you can do best to create a better world for humanity to thrive upon without fear of old age and other symptoms of age-related degenerative diseases”- Lou Baron
Said book is based on years of painstaking research and recent discoveries on stem cell therapy pioneered by her better half, Dr. Robinson Baron, an esteemed general, robotic, and stem cell surgeon.
The book’s goal is to educate people about the direction and to get stem cells accepted in the mainstream.
Stem cell therapy has the potential to transform the healthcare system as we know it.
Kitamura, Y. et al. (2021). Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Scientific Advances. DOI: 10.1126/sciadv.abe8671
Engineered 'off-the-shelf' stem cells target breast cancer that metastasizes to the brain
Harvard Stem Cell Institute (HSCI) researchers have engineered stem cells that can deliver a tumor-suppressing and…