ALS or amyotrophic lateral sclerosis is a deadly neurodegenerative disease that progresses fast. Symptoms include inflammation of the nerve cells and loss of motor skills. Those affected by ALS suffer from voluntary muscle control and begin to have problems with speaking, walking, running, and even breathing. This is because as the disease progresses, nerve cells begin to die at a high-speed rate. Over time, without timely medical interventions, the disease will paralyze the patient, and this often results in death due to respiratory failure.
Because of the speed at which ALS progresses, scientists are rushing to find immediate treatment. Medical researchers are seeing a glimmer of hope with the help of cell-based therapy.
What is Cell-based therapy?
Cell-based therapy makes use of a patient’s or donor cells to treat a disease. And it has great potential to cure many other diseases including Parkinson’s, Alzheimer’s, and various forms of cancer including heart failure.
Mesenchymal Stem Cells
Mesenchymal stem cells are sourced from the adult bone marrow, and they secrete high levels of molecules known as factors that enhance the growth of the nerve tissue.
These nerve tissue stem cells promote the production of molecules in the cerebral spinal fluid that protects nerve tissue. Researchers believe that if ALS patients were injected with fresh mesenchymal stem cells, it could potentially hamper the progression of ALS symptoms.
In order to test their hypothesis, numerous clinical trials were done by various credible institutions like the University of Stanford and the University of Arizona. A group of researchers recruited 189 patients who suffer from ALS who are aged 18 to 60 and divided them into two groups. The first one is a placebo group, and the other one is a test group. The study was conducted double-blinded, meaning the researchers, patients, lab technicians, and all involved in the clinical process do not know which group is the placebo. One-half of the group received stem cell treatment, and the other group a placebo. About 45 patients had to drop out of the procedure before it was even finished, mostly males who were in their 40s.
The ones who remained were given a test called the ALSFRS-R, or the ALS Functional Rating Scale-Revised. This test works by giving each patient a simple motion task to do. They are then scored from 0 ( which meant they cannot move at all) to 4 ( they can perform normal motion). The lower the score of the patient, the worse the progression of the ALS disease.
Each month, patients' motor skills were monitored, and cerebral spinal fluid samples were taken from them.
Patients who were provided with stem cell treatments showed improvement in their biomarkers. Biomarkers indicate if a person is responding to a certain treatment being provided to them. They had an increase in a protein called VEGF that promotes new blood vessels and their NfL levels were also lower which means they had fewer dead neurons compared with ALS patients who were only given a placebo.
This positive progression in the clinical trials is giving medical researchers hope that Mesenchymal stem cells hold one of the keys to solving or treating ALS in the near future. And while Mesenchymal stem cells cannot in theory stop the progression of ALS, they can still give future improvements and much-needed hope for ALS patients.
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Stem Cell Advocates
Stem Cell therapy also led to the incremental improvements that allow Lourdes Duque Baron and Michael York to continue living with amazing energy and boosted immune systems.
Receivers of billions of stem cells both attest to the truth of this rejuvenating and immensely powerful treatment.
Michael York a highly respected A-list actor became an advocate for stem cells after receiving treatment for his Amyloidosis and Multiple Myeloma.
Stem Cell advocate Lou Baron and Michael York
While 75-year-old Lourdes Duque Baron experienced the healing of her Osteoporosis by way of stem cell therapy.
NEW BREED OF HOMO SAPIENS
To further understand the immense value and possibilities of stem cell therapy Lourdes Duque Baron, a staunch stem cell awareness advocate will release the book New Breed of Homo Sapiens.