Cellular Senescence & the Secrets to healthier Aging
As we grow older our body has a harder time fighting disease and healing from injuries. Our immune system is not as efficient, and no longer as effective in removing deteriorating cells, and this is what leads to a weaker immune system and hampered biological processes.
Despite all the existing research and availability of medicines and vaccines, we have yet to solve the real problem that is ailing the human body. This leads scientists to get interested in learning a cellular state called “ Senescence”.
A cellular state called “ senescence”- during which damaged cells resist removal by apoptosis, stay behind, and begin harming neighboring normal cells- researchers believe that it holds the key to re-invigorating aging tissues while increasing healthy, active years of remaining life.
Understanding Cellular Senescence
Senescent cells are one of a kind, and they eventually stop multiplying but don’t die as they should. Instead, they remain and continue to release chemicals that are responsible for inflammation in the body. Even just a small amount of senescent cells left can spread inflammation and multiply damage in cells.
But it is important to note, that not all senescent cells are bad. There are what we call senescent secretome- compounds and molecules that are expressed by senescent cells and they play a major role in the human lifespan starting from the development of the embryo, childbirth, and participation in wound healing.
Cellular Senescence and how it impacts the body?
The existing amount of senescent cells in our body increases as we get older. Our aging immune system becomes less efficient, and this is when senescent cells further increase and impact the cells negatively.
When there is a high amount of senescent cells, we have a harder time coping with illness, stress, and injuries. The human mind has a harder time learning new things because senescent cells have the ability to incapacitate cognitive function.
Cellular Senescence is deemed to be the culprit of age-related conditions. It has a connection to health conditions like Cancer, Osteoporosis, diabetes, cardiovascular disease, stroke, dementia, osteoarthritis, and Alzheimer’s disease.
It is linked with a decline in muscle strength, blurry eyesight, memory lapses, and even issues with muscle strength and skeletal issues. It is also under investigation as to its connection with the wrinkling and sagging of the skin.
Doctors and researchers are tired of prescribing the latest innovations in walkers, wheelchairs, bladder incontinence because they do not really solve the problem. It is best to look into the real problem, so the main solution can be created. Is there a way for us to reverse or hamper the fundamental signs of aging?
I think I’m chock full of bad senescent cells. They start accumulating when you hit age 60, and from there it’s kind of an exponential increase. Toward the end of life, depending how you’re aging, up to 10% of certain tissues can have at least some markers of senescence.
— Paul Robbins, Ph.D
Paul Robbins, Ph.D. is suggesting that before one goes for surgery, you might want to clear your bad senescent cells first so chances of recovery will be high.
There is also a need to sort out the good senescent cells from the bad senescent cells.
Senescent cells are the key to understanding diseases like cancer, and what really leads to aging and other age-related disease.
Some clinical trials already tested the theory using various mouse models. Researchers eliminated senescent cells from the aging mouse, and the results are phenomenal. The lifespan of the mouse increased and the disease progression was hampered. The only question now is, will this technique also be possible with humans?
Currently, medical doctors and researchers are looking into using senolytic treatments with the aim of reducing the harmful effects of treatments for HIV/AIDS and chemotherapy.
What science knows so far is that there are good senescent cells that aid in tissue repair, healing, embryonic development, and the phase of childbirth. But there are also bad ones that cause illnesses and inflammation. The idea now is to come up with a way to separate the good ones from the bad ones, in a safe and effective manner.
The idea is to map and manipulate senescence-related proteins that are usually involved with the build-up of beta-amyloid plaques and neuroinflammation that leads to illnesses like Alzheimer’s disease.
There is a need to develop biomarkers, to measure and check the presence of the disease. To find ways and tools to better find and target senescent cells that are present in different tissues. And eventually come up with drugs that can eliminate senescent cells, without damaging the neighboring healthy cells.
Overview of Cell Senescence - SENS Research Foundation
Researchers have found that senescent cells accumulate in our body as we age. Deciphering the purpose, causes, and…
Why Is Senescence Research Important?
The link between aging and senescent cells can no longer be denied. Research in rodents shows that selectively removing senescent cells in vivo does reduce inflammation in the body, enhances the immune system, and slows down the progression of age-related diseases leading to a healthier mind and body and a longer lifespan.
Mesenchymal Stem Cell-Based Therapy
Mesenchymal stem cells are taken from the bone marrow, umbilical cord, adipose tissue. It is now being used for an array of clinical applications due to its high efficacy.MSCs are preferred by many doctors due to their high acceptance rate in the body.
MSC-based regeneration has the ability to replace cells that are lost or impaired by disease with functional cells. Mesenchymal stem cells senescence both in vivo and in vitro can affect MSC characteristics, which has important clinical and safety implications.
Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and…
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and differentiation. There is increasing…
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