Seeding stem cells into the human brain may cure Parkinson’s disease
Medical researchers from Arizona State University are focusing on a new and exciting cure for the motor symptoms of Parkinson’s disease.
Parkinson’s is a devastating disease, apart from hindering a person from living everyday life, it eventually progresses to a point wherein the patient suffering loses their ability to walk. It affects over 10 million people worldwide making it a big cause of concern.
Parkinson’s disease attacks the neurons, the disease damages them and eventually destroys everything it is a path.
One of the first signs of Parkinson’s disease is uncontrollable movements, stiffness, shaking, and difficulty with coordination and balance. This occurs because a specific group of neurons in the midbrain are damaged. The ability of the brain to produce dopamine is impaired. But the good news is that stem-cell-derived neural grafts that were tested on mice provided immense positive results.
Replacing Neurons
Doctors and medical researchers are super excited because they now have the opportunity to find a super cure for Parkinson’s disease in the form of stem cell therapy. While it is true that it is still under trial, only mice responded positively to the treatments using stem cell therapy. It is still positive progress toward finding the cure for Parkinson’s.
The Arizona State University describes the process as non-neuronal cells converting into functioning neurons that have the ability to connect to the living brain after implantation. This forms into synapses then secrete dopamine and restore some of the brain's vital functions that were damaged because of Parkinson’s disease.
During the clinical study using lab rats, researchers were able to prove that there are types of stem cells that work best for the task, and are responsive to brain grafts for treating motor symptoms of Parkinson’s.
They tested two types of stem cells. The first one is adult stem cells that are sourced from bone marrow, skin, and liver. The second category of stem cells that they used is Pluripotent stem cells. They grew red blood stem cells and reprogrammed them. These cells revert to the state of the embryonic stem cells and differentiate into whatever mature cell type is needed.
The research team cultured iPSCs for 17, 24, and 37 days. All batches successfully transformed into the desired type of neurons, while those that were cultured for 17 days proved to be the best team for the task at hand. These batches survived longer, and in great numbers compared with the others. This batch also grew longer axons and dendrites, or what we call the wiring that connects neurons in the brain allowing them to interact, transmit and process information faster.
Laboratory rats that were given these grafts using the 17-day iPSCs showed amazing recovery from the motor symptoms of Parkinson’s disease. Those that received large doses of stem cells improved immensely, while those that received less showed minimal improvements. There had been a complete reversal of symptoms for mice who received larger volumes of a fresh batch of stem cells.
Encourage by these amazing results, the team plans to further the research on human subjects. Focusing on patients who suffer from Parkinson's disease mutations, that often suffer from motor issues as well as dementia.
Stem Cell therapy will be combined with other existing therapy options to better fight the disease. Researchers are also hopeful for patients with Huntington’s disease and multiple system atrophy, even those who have Alzheimer’s disease.
This research paper study was released in the Journal of Regenerative Medicine titled Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease”.
Feeling Good At Any Age The One Stop Rejuvenation Center ( FGAAA) in West Covina, California is one of the leading stem cell therapy clinics in the world that offer premium quality products and the latest available stem cell treatments for a variety of health conditions like chronic heart failure, chronic kidney disease, and type 1 diabetes, among others.
Stem Cell Advocates
Stem Cell therapy also led to the incremental improvements that allow Lourdes Duque Baron and Michael York to continue living with amazing energy and boosted immune systems.
Receivers of billions of stem cells both attest to the truth of this rejuvenating and immensely powerful treatment.
Michael York a highly respected A-list actor became an advocate for stem cells after receiving treatment for his Amyloidosis and Multiple Myeloma.
Stem Cell advocate Lou Baron and Michael York
While 75-year-old Lourdes Duque Baron experienced the healing of her Osteoporosis by way of stem cell therapy.
NEW BREED OF HOMO SAPIENS
To further understand the immense value and possibilities of stem cell therapy Lourdes Duque Baron, a staunch stem cell awareness advocate will release the book New Breed of Homo Sapiens.
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