Stem Cell Therapy & Traumatic Brain Injury
Traumatic Brain injury is dangerous and fatal. There is no effective drug treatment so far.
To reduce damage, most clinics and hospitals make use of brain stimulation, behavioral therapy, electric stimulation, and hyperbaric oxygen. However, results are not as good and long-lasting. Therefore, clinicians and medical researchers are studying the use of stem cells to heal and enhance the brain.
Researchers found that Exogenous stem cells are far more effective when treating brain injury. It can migrate to damaged brain tissue and repair it through differentiation. It replaces damaged cells, and releases anti-inflammatory factors, leading to improved neurological function.
In 2018, researchers discovered that a variety of stem cells like mesenchymal, neural, and multipotent adult progenitor cells can treat neurological impairments.
Mesenchymal Stem Cells taken from the bone marrow could be used for tissue regeneration. It replaces damaged tissues and reduce inflammation. It replaces lost cells and enhances the ability of the body to accelerate the repair of intracranial aneurysms.
MSC’s was proven to help speed up the healing of traumatic brain injury in laboratory mice. Bone marrow derived stem cells were injected in mice, and clinical studies proved that it was able to boost learning and memory ability of the mice. It also reduced the oxidative stress and inflammation of bodily organs.
Because of this promising research, doctors and medical researchers are much more confident in using Mesenchymal stem cells in clinical trials.
In one study (Zhang et., al 2008) 7 patients were transplanted with mesenchymal stem cells during craniocerebral surgery. The surgeons injected MSC’s directly to the injured brain tissue of patients with traumatic brain injury. These patients showed amazing and significant improvement after 6-months of follow-up, and no toxicity or side effects were found. During further clinical trials, no adverse reactions nor death that has occurred making it relatively safe.
The only thing that surgeons want to perfect now is the exact formula as to how many mesenchymal stem cells should be given to patients. How many and how regular should these treatments be, that is the remaining question.
These studies give hope for Traumatic brain injury patients. When combined with a healthy diet, emotional, psychological, and spiritual support, the chances of improving from traumatic brain injury are higher.
There are still a lot of problems that need to be solved when it comes to using stem cells in brain injuries. But the clinical studies have achieved amazing therapeutic results. A good number of basic studies have already confirmed the good effect of stem cells in dealing with the craniocerebral injury. Including the safety of stem cells administered by way of injection.
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References
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