Can stem cell transplantation into the human brain cure Parkinson’s disease?
Parkinson’s disease is a devastating disease that, in addition to making daily life difficult, eventually leads to the patient losing their ability to walk.
Parkinson’s disease attacks neurons, causing them to deteriorate and eventually destroying everything in its path.
Uncontrollable movements, stiffness, shaking, and difficulty with coordination and balance are among the first symptoms of Parkinson’s disease. This occurs as a result of damage to a specific group of neurons in the midbrain. The brain’s ability to produce dopamine is impaired. The good news is that stem-cell-derived neural grafts tested on mice produced enormously positive results.
Neuron Replacement
Arizona State University medical researchers are working on a novel and exciting cure for Parkinson’s disease’s motor symptoms.
Doctors and medical researchers are ecstatic because stem cell therapy offers the possibility of finding a super cure for Parkinson’s disease. While the treatments using stem cell therapy are still being tested, only mice responded positively to them. It is still a step forward toward finding a cure for Parkinson’s disease.
According to Arizona State University, the process involves non-neuronal cells converting into functioning neurons that can connect to the living brain after implantation. It forms synapses that secrete dopamine and restores some of the brain’s vital functions that have been compromised because of Parkinson’s disease.
Using lab rats, researchers demonstrated that certain types of stem cells work best for the task and are responsive to brain grafts for treating Parkinson’s motor symptoms.
They examined two kinds of stem cells. The first is adult stem cells derived from bone marrow, skin, and liver. Pluripotent stem cells are the second type of stem cell that they made use of. They grew and reprogrammed red blood stem cells. These cells revert to the embryonic stem cell state and differentiate into whatever mature cell type is required.
iPSCs were cultured for 17, 24, and 37 days by the research team. All batches successfully transformed into the desired type of neurons, with those cultured for 17 days proving to be the best team for the job.
When compared to the others, these batches survived longer and in greater numbers. This group also developed longer axons and dendrites, or the wiring that connects neurons in the brain, allowing them to interact, transmit, and process information more quickly.
Laboratory rats given these grafts made from 17-day iPSCs recovered miraculously from Parkinson’s disease motor symptoms. Those who received large doses of stem cells improved dramatically, while those who received less improved only marginally. Larger doses of a fresh batch of stem cells resulted in a complete reversal of symptoms in mice.
Encouraged by these remarkable results, the team intends to expand its research on human subjects. Focusing on patients with Parkinson’s disease mutations, who frequently have motor issues as well as dementia.
To combat the disease more effectively, stem cell therapy will be combined with other existing treatment options.
This study, titled “Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease,” was published in the Journal of Regenerative Medicine.
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New Breed of Homo Sapiens
Stem cell therapy has also resulted in incremental improvements, allowing Lourdes Duque Baron and Michael York to continue living with incredible energy and immune systems.
Both recipients of billions of stem cells attest to the efficacy of this rejuvenating and enormously powerful treatment.
After being treated for Amyloidosis and Multiple Myeloma, Michael York, a well-known A-list actor, became an advocate for stem cells.
While 75-year-old Lourdes Duque Baron received stem cell therapy to treat her osteoporosis.
Lourdes Duque Baron, a staunch stem cell awareness advocate, will release the book New Breed of Homo Sapiens to further understand the immense value and possibilities of stem cell therapy.
Research Credits:
https://www.zmescience.com/science/stem-cell-brain-parkinsons-treatment-846346234/